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Anti-Mi2β Dermatomyositis in Active Disease

Dermatomyositis (anti-Mi2β+) Severe Myositis-Associated Microangiopathy Severe

A 32-year-old woman with active anti-Mi2β-positive dermatomyositis and marked microvascular damage on capillaroscopy.

Author Gema María Lledó Ibáñez

Clinical context

After 3 months of progressive symptoms, diagnosis was established based on proximal muscle weakness, Gottron papules, heliotrope rash, and hyperCKemia (~2500).

Capillaroscopy

There is marked capillary loss (4.8/mm), architectural disorganization, frequent dilations, giant capillaries, and abnormal/branched shapes, indicating severe active microangiopathy.

Key Capillaroscopic Findings

Severe capillary loss (4.8/mm)
Giant capillaries (8.8%) and frequent dilations (59.4%)
Abnormal/branched capillaries (32.1%) with vascular remodeling